{"id":3532,"date":"2016-08-30T09:57:42","date_gmt":"2016-08-30T12:57:42","guid":{"rendered":"https:\/\/prodoctor.net\/blog\/?p=3532"},"modified":"2025-06-23T17:48:21","modified_gmt":"2025-06-23T20:48:21","slug":"droga-anti-hiv-tem-acao-positiva-contra-alzheimer","status":"publish","type":"post","link":"https:\/\/prodoctor.net\/blog\/droga-anti-hiv-tem-acao-positiva-contra-alzheimer\/","title":{"rendered":"Droga anti-HIV tem a\u00e7\u00e3o positiva contra Alzheimer"},"content":{"rendered":"

O Mal de Alzheimer<\/strong> atinge cerca de 6% das pessoas com idade acima de 65 anos<\/strong> e apresenta como primeiro sintoma mais comum a perda de mem\u00f3ria a curto prazo<\/strong>. A doen\u00e7a, degenerativa<\/strong>, ainda n\u00e3o tem cura<\/strong>, mas a incessante luta dos pesquisadores nas melhores formas de tratamento tem apontado algumas dire\u00e7\u00f5es com avan\u00e7os significativos.<\/p>\n

Algumas vezes, trilhando at\u00e9 mesmo caminhos inesperados e curiosos, como a recente descoberta<\/strong> revelada por cientistas do National Insitute of Standards of Technology (NIST) e da Western Reserve University, nos Estados Unidos.<\/p>\n

O alento surgiu atrav\u00e9s dos antirretrovirais<\/strong> usados no combate ao desenvolvimento do v\u00edrus HIV<\/strong> em portadores desta enfermidade. Conforme o estudo divulgado pelo \u201cJournal of Biological Chemistry\u201d<\/em>, o efavirenz<\/strong>, princ\u00edpio ativo de um medicamento recentemente aprovado contra o HIV<\/strong>, se liga \u00e0 enzima CYP46A1, aumentando sua capacidade de eliminar o colesterol do c\u00e9rebro<\/strong>.<\/p>\n

Segundo o relato, estudos em animais detectaram uma menor presen\u00e7a da gordura no \u00f3rg\u00e3o est\u00e1 associada \u00e0 melhora da mem\u00f3ria<\/strong>. Nas experi\u00eancias realizadas com ratos, a liga\u00e7\u00e3o da enzima com a droga provocou um aumento de 40% na remo\u00e7\u00e3o do colesterol do \u00f3rg\u00e3o<\/strong>. Al\u00e9m disso, os cientistas ficaram animados quando certificaram que a aus\u00eancia da CYP46A1 provocou problemas de aprendizagem nos roedores.<\/p>\n

Os trabalhos na Western Reserve est\u00e3o sendo desenvolvidos h\u00e1 anos pela equipe m\u00e9dica liderada pela Dra. Irina Pikuleva, que pesquisa estrat\u00e9gias envolvendo a enzima CYP46A1. Ela acredita ser prov\u00e1vel que o impulso para a a\u00e7\u00e3o da enzima seja ainda maior<\/strong>, pois em humanos desempenha um papel maior que nas cobaias<\/strong>.<\/p>\n

Estudos anteriores revelaram que a CYP46A1 consegue diminuir a presen\u00e7a da beta-amil\u00f3ide<\/strong>, um tipo de gordura encontrada em altas quantidades em pacientes com Alzheimer<\/strong>, sendo capaz de bloquear a sinaliza\u00e7\u00e3o entre os neur\u00f4nios.<\/p>\n

Segundo os cientistas, a enzima responde sozinha<\/strong> e de forma positiva pela elimina\u00e7\u00e3o de 80% do colesterol do c\u00e9rebro<\/strong>, constatando-se que pequenas doses do antirretroviral j\u00e1 aumentam a capacidade intr\u00ednseca da prote\u00edna.<\/p>\n

Seguindo nesta dire\u00e7\u00e3o, a Dra. Irina Pikuleva e seus colegas agora v\u00e3o \u00e0 procura de financiamento para realizarem um ensaio cl\u00ednico em humanos<\/strong>. O objetivo \u00e9 verificar o potencial do medicamento nos pacientes com o Mal de Alzheimer<\/strong>, investigando seus potenciais efeitos terap\u00eauticos ao ministrar pequenas doses da droga.<\/p>\n

– As evid\u00eancias sugerem fortemente que, em doses menores, efavirenz pode ser uma terapia eficaz para estimular a degrada\u00e7\u00e3o do colesterol c\u00e9rebro e abrandar ou prevenir a doen\u00e7a de Alzheimer<\/strong> \u2013 declarou Pikuleva ao \u201cJournal of Biological Chemistry\u201d.<\/p>\n

Tecnologia ajudando pacientes de Alzheimer e seus familiares<\/h3>\n

Confira, aqui<\/a>, alguns exemplos de como a tecnologia<\/strong> tem desempenhado um papel importante na procura de novas formas para minimizar os efeitos do Alzheimer<\/strong> para os portadores da doen\u00e7a e tamb\u00e9m de seus familiares.<\/p>\n","protected":false},"excerpt":{"rendered":"

O Mal de Alzheimer atinge cerca de 6% das pessoas com idade acima de 65 anos e apresenta como…<\/p>\n","protected":false},"author":1,"featured_media":19692,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[415,413],"tags":[],"class_list":["post-3532","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicamentos-e-farmacia","category-medicina-e-saude"],"yoast_head":"\nEstudo aponta que droga anti-HIV pode beneficiar pacientes com 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