{"id":11884,"date":"2019-05-03T11:29:10","date_gmt":"2019-05-03T14:29:10","guid":{"rendered":"https:\/\/prodoctor.net\/blog\/?p=11884"},"modified":"2021-07-19T10:11:34","modified_gmt":"2021-07-19T13:11:34","slug":"uso-de-nanofarmacos-pode-ser-eficiente-para-tratar-doenca-de-pele","status":"publish","type":"post","link":"https:\/\/prodoctor.net\/blog\/uso-de-nanofarmacos-pode-ser-eficiente-para-tratar-doenca-de-pele\/","title":{"rendered":"Uso de nanof\u00e1rmacos pode ser eficiente para tratar doen\u00e7a de pele"},"content":{"rendered":"

No Instituto de Ci\u00eancias Biom\u00e9dicas (ICB)<\/a> da USP, pesquisa prop\u00f5e um novo m\u00e9todo de tratamento para a psor\u00edase, doen\u00e7a inflamat\u00f3ria que provoca vermelhid\u00e3o, descama\u00e7\u00e3o e placas na pele.<\/strong> O estudo mostrou os benef\u00edcios da aplica\u00e7\u00e3o t\u00f3pica na pele, na forma de lo\u00e7\u00e3o, gel ou creme, de nanocarreadores, mol\u00e9culas que cont\u00e9m compostos doadores de sulfeto de hidrog\u00eanio (H2S).<\/p>\n

Essas mol\u00e9culas, chamadas de nanof\u00e1rmacos<\/strong>, inibem a produ\u00e7\u00e3o de citocinas<\/strong> que estimulam a instala\u00e7\u00e3o do processo inflamat\u00f3rio \u2013 elas s\u00e3o produzidas em grandes quantidades em pacientes com psor\u00edase ou outras inflama\u00e7\u00f5es cr\u00f4nicas.<\/p>\n

As prepara\u00e7\u00f5es farmac\u00eauticas de doadores de H2S<\/strong> j\u00e1 foram patenteadas pelo grupo. Os efeitos farmacol\u00f3gicos do H2S na psor\u00edase foram descobertos no laborat\u00f3rio dos professores Soraia Costa e Marcelo Muscar\u00e1, do Departamento de Farmacologia do ICB. <\/strong><\/p>\n

A equipe testou uma terapia com doadores de H2S por aplica\u00e7\u00e3o sist\u00eamica (inje\u00e7\u00f5es intraperitoneais) para tratar a doen\u00e7a. A psor\u00edase \u00e9 uma doen\u00e7a inflamat\u00f3ria cr\u00f4nica e imunomediada<\/strong>, com manifesta\u00e7\u00f5es cut\u00e2neas (vermelhid\u00e3o, descama\u00e7\u00e3o e placas na pele) e sist\u00eamicas (por todo o corpo).<\/p>\n

A partir dos testes pr\u00e9-cl\u00ednicos, descobriu-se que a subst\u00e2ncia \u00e9 capaz de atuar beneficamente no tratamento dessa inflama\u00e7\u00e3o, inibindo a produ\u00e7\u00e3o de citocinas pr\u00f3-inflamat\u00f3rias.<\/strong> O passo seguinte foi integrar essa descoberta \u00e0s pesquisas da equipe da professora Luciana Lopes<\/strong>, tamb\u00e9m do Departamento de Farmacologia, que se concentram na formula\u00e7\u00e3o de nanof\u00e1rmacos, visando \u00e0 melhora da efic\u00e1cia terap\u00eautica e \u00e0 redu\u00e7\u00e3o dos efeitos adversos de f\u00e1rmacos.<\/p>\n

Foi nesta etapa que foi desenvolvida a estrat\u00e9gia de nanocarreadores<\/strong> com os compostos doadores de H2S.<\/p>\n

Penetra\u00e7\u00e3o na pele<\/h2>\n

\"Penetra\u00e7\u00e3o<\/p>\n

\u201c\u00c9 um desafio atravessar o estrato c\u00f3rneo (parte mais externa) da pele para chegar \u00e0s camadas onde se desenvolve a doen\u00e7a \u2013 por isso usamos os nanocarreadores\u201d, explica Luciana. \u201cPor outro lado, dependendo da profundidade e extens\u00e3o da penetra\u00e7\u00e3o cut\u00e2nea<\/strong>, pode haver absor\u00e7\u00e3o e efeitos sist\u00eamicos (em todo o corpo).<\/p>\n

Assim, outro desafio foi localizar o f\u00e1rmaco na pele para obter apenas o efeito local\u201d, explica Luciana Lopes.<\/p>\n

O tratamento tradicional para a psor\u00edase envolve o uso de corticoides<\/strong> \u2013 medicamentos que apresentam uma s\u00e9rie de efeitos colaterais indesejados. Com o uso prolongado desses f\u00e1rmacos, os pacientes podem desenvolver alguns quadros cl\u00ednicos adversos, tais como a s\u00edndrome de Cushing (ganho de peso ao redor do tronco e perda de massa nos bra\u00e7os e pernas), maior suscetibilidade a infec\u00e7\u00f5es, diminui\u00e7\u00e3o da espessura da pele e at\u00e9 supress\u00e3o da fun\u00e7\u00e3o das gl\u00e2ndulas suprarrenais.<\/p>\n

\u201cOs nanof\u00e1rmacos de compostos doadores de H2S<\/strong> podem substituir ou diminuir o uso do corticoide em casos n\u00e3o severos de psor\u00edase\u201d, esclarece Soraia. \u201cPor exemplo, seria poss\u00edvel iniciar o tratamento com essa alternativa para controlar a doen\u00e7a e s\u00f3 aplicar o corticoide quando necess\u00e1rio. Isso evitaria ou reduziria os efeitos adversos que o uso prolongado destes medicamentos ocasiona\u201d.<\/p>\n

As pesquisas s\u00e3o fruto da disserta\u00e7\u00e3o de mestrado<\/strong> de Tuanny Schimidt e da tese de doutorado de Leandro Rodrigues. Os estudos foram orientados pela professora Soraia Costa.<\/p>\n

Fonte:\u00a0Acad\u00eamica Ag\u00eancia de Comunica\u00e7\u00e3o \/ Jornal da USP<\/a><\/p>\n

\u00a0Leia mais:\u00a0<\/strong>Startup auxilia ind\u00fastria na destina\u00e7\u00e3o social de medicamentos<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

No Instituto de Ci\u00eancias Biom\u00e9dicas (ICB) da USP, pesquisa prop\u00f5e um novo m\u00e9todo de tratamento para a psor\u00edase, doen\u00e7a…<\/p>\n","protected":false},"author":1,"featured_media":20339,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_kad_blocks_custom_css":"","_kad_blocks_head_custom_js":"","_kad_blocks_body_custom_js":"","_kad_blocks_footer_custom_js":"","_kadence_starter_templates_imported_post":false,"_kad_post_transparent":"","_kad_post_title":"","_kad_post_layout":"","_kad_post_sidebar_id":"","_kad_post_content_style":"","_kad_post_vertical_padding":"","_kad_post_feature":"","_kad_post_feature_position":"","_kad_post_header":false,"_kad_post_footer":false,"footnotes":""},"categories":[415],"tags":[],"class_list":["post-11884","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicamentos-e-farmacia"],"yoast_head":"\nUso de nanof\u00e1rmacos pode ser 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